Assessment of the biological efficacy of gold Nannochloropsis oculata nano-extract against lithium-induced toxicity in rats.

ABSTRACT: Chronic renal impairment can be caused by prolonged exposure to lithium (Li), which is considered a prototype medication for the treatment of bipolar disorders (BDs). The current study aimed to enhance the biological efficacy of biosynthesized gold nanoparticles (Au-NPs) using an algal extract from Nannochloropsis oculata to mitigate the neurotoxicity and kidney damage induced by Li in rats. The kidney and brain tissues were analyzed using conventional biochemical tests to assess oxidative stress and inflammatory responses. Electrophoretic techniques were used to examine native protein and isoenzyme patterns. Histopathological analysis was conducted on both tissues. mRNA expression levels of inflammatory markers (NF-κB, IL-6, and IL-1β) and antioxidant enzymes (SOD1, CAT, and GPx1) were al

SUBMITTER: Bekheit RA 

PROVIDER: S-EPMC12835123 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature