Occupational exposure and risk clusters in malignant transformation of inverted sinonasal papilloma.

ABSTRACT: Inverted sinonasal papilloma (ISP) is a benign epithelial neoplasm with potential for malignant transformation into squamous cell carcinoma (ISP-SCC). While high-risk HPV infection has been studied as a possible driver, other factors, including occupational exposures, may play a role. Thirty-two cases (n = 32) of ISP and ISP SCC were retrospectively analysed. These cases had been diagnosed between 2010 and 2022. We assessed their occupational history through the Italian Sino-Nasal Cancer Registry questionnaire and performed p16/p53 immunohistochemistry, HPV DNA and RNA testing. Overall, 41% of ISP and 40% of ISP-SCC cases reported exposure to IARC Group 1-2 A carcinogens, and 69% had a history of smoking. Transcriptionally active HPV was detected in only one case (3.1%). Conventional bivar

SUBMITTER: Querzoli G 

PROVIDER: S-EPMC12835149 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature