Metabolic profiles of amino acids in patients with crohn's disease-associated perianal fistulas and cryptoglandular anal fistulas.

ABSTRACT: Crohn's disease-associated perianal fistulas (PFCD) and Cryptoglandular anal fistulas (CAF) are two types of fistulas with similar clinical manifestations but distinct etiologies and therapeutic strategies. This study aims to investigate serum amino acid metabolic profiles in patients with CAF and PFCD based on UPLC-MS/MS. Serum samples were enrolled from newly diagnosed and treatment-naïve 36 patients with active PFCD and 36 patients with CAF as controls. Clinical characteristics were systematically documented. Serum concentrations of 25 amino acids were quantitatively determined using UPLC-MS/MS with isotopically labeled internal standards. Multivariate statistical analyses were employed to discriminate metabolic profiles between groups. Pathway enrichment analysis of differential amino

SUBMITTER: Ma K 

PROVIDER: S-EPMC12835150 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature