Multicohort assessment of plasma metabolic signatures of tuberculosis disease in children: a retrospective cross-sectional study.

ABSTRACT: Microbiological tests for tuberculosis (TB) disease in children have suboptimal accuracy and respiratory samples are often challenging to obtain. Using liquid chromatography/mass spectrometry, we performed plasma high-resolution metabolomics (HRM) to identify blood-based biomarkers associated with TB disease in children. We analyzed plasma samples from 438 children 0-14 years being evaluated for TB disease in India, Peru, Uganda, The Gambia, and South Africa. All children underwent a standard clinical evaluation and were followed up after 3 months. Children were classified as Confirmed (n = 104), Unconfirmed (n = 108), or Unlikely TB (n = 226) as per NIH consensus definitions. Controlling for age and study site, we found creatine, alanine, retinol, citrulline, fumarate, and tryptophan to b

SUBMITTER: Nellis MM 

PROVIDER: S-EPMC12835163 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature