Annexin A2 Causes Motor Incoordination via Muscle-Cerebellum Axis in Sarcopenia.

ABSTRACT:

Background

Sarcopenia is a prevalent age-related disorder characterized by progressive muscle atrophy. Impaired balance is one of its most critical clinical consequences, often leading to falling and even bone fractures. As the cerebellum plays a central role in regulating motor coordination, elucidating the molecular mechanisms underlying imbalance in sarcopenia, particularly those mediated by the muscle-cerebellum axis, remains an important yet unresolved question.

Methods

4D label-free proteomics was employed to identify the key secretory protein mediating the interaction between muscles and cerebellums in young and aged mice. Annexin A2 (ANXA2), the candidate protein, was subsequently overexpressed using adeno-associated virus (AAV), and its effects on both muscle and ce

SUBMITTER: Jiao X 

PROVIDER: S-EPMC12835187 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature