Phage therapy against methicillin-resistant Staphylococcus pseudintermedius: a novel strategy for canine pyoderma.

ABSTRACT:

Introduction

Methicillin-resistant Staphylococcus pseudintermedius (MRSP) poses a major public health challenge due to its multidrug resistance. Phages represent an innovative therapeutic strategy with considerable potential against drug-resistant bacterial infections.

Methods

In this study, dogs clinically diagnosed with pyoderma were recruited to establish an epidemiological dataset, and multidrug-resistant S. pseudintermedius strains (including 6 MRSP isolates) were obtained from bacterial cultures. Three high-efficiency lytic phages were isolated using these MRSP strains as hosts and characterized. The combined efficacy of phages and antibiotics was evaluated in a pyoderma model via clinical scoring, histopathological examination, and tissue bacterial load

SUBMITTER: Feng X 

PROVIDER: S-EPMC12835223 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature