Serum extracellular vesicle RNA profiles in long COVID: insights from exercise-induced gene modulation.

ABSTRACT: The Persistence of SARS-CoV-2 in tissues has been proposed as a driver of prolonged symptoms in long COVID. Pulmonary rehabilitation with exercise training is a well-established intervention for improving symptoms, functional capacity, and inflammation in chronic cardiorespiratory diseases. To investigate whether long COVID is associated with persistent viral or immune-related signals, we analyzed the long RNA profile of circulating extracellular vesicles (EVs) to determine the presence of virus-related transcripts and assess changes in response to exercise training. Fourteen adults with long COVID participated in this single-center pilot clinical trial and completed a 10-week aerobic exercise training program (twenty 1.5 h sessions). Serum-derived EV RNA profiles were analyzed via sequenc

SUBMITTER: Abbasi A 

PROVIDER: S-EPMC12835237 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature