Association between intravenous magnesium sulfate and mortality in patients with sepsis-associated liver injury: a retrospective cohort study.

ABSTRACT:

Background

Sepsis-associated liver injury (SALI) is a significant risk factor for mortality in patients with sepsis. Magnesium, as an essential electrolyte, has a correlation with adverse outcomes in critical illness when deficient, yet the therapeutic efficacy of magnesium sulfate in SALI remains undetermined. This study was designed to evaluate the association between magnesium sulfate therapy and prognosis in SALI patients.

Method

This retrospective cohort study utilized data from the Medical Information Mart for Intensive Care IV (MIMIC-IV) database, with the primary endpoint being 30-day all-cause mortality.Propensity score matching (PSM) achieved covariate balance, Kaplan-Meier survival curves and Cox regression were employed to analyze the magnesium sulfate-mortality

SUBMITTER: Ouyang C 

PROVIDER: S-EPMC12835258 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature