Six-year epidemiological dynamics of human respiratory syncytial virus infections in children in central China (2019-2024): pandemic suppression, 2023 resurgence, and immune debt effect.

ABSTRACT:

Background

Human respiratory syncytial virus (HRSV) is a leading cause of acute respiratory infections in children. COVID-19 NPIs significantly suppressed HRSV transmission. This study analyzed six-year epidemiological dynamics of pediatric HRSV infections in Henan Province, China, focusing on NPI suppression effects, the 2023 resurgence, and "Immune debt" impact.

Methods

We retrospectively collected respiratory specimens from 80,920 children with acute respiratory diseases at Henan Children's Hospital (2019-2024). HRSV was detected using RT-qPCR. Positivity rates were analyzed by year, season, and age group.

Results

During 2019-2024, HRSV positivity fluctuated markedly: 14.65% (2019), 16.34% (2021), 3.27% (2022 under strict NPIs), 21.47% (2023 post-NPIs), and 6.80% (

SUBMITTER: Xia Z 

PROVIDER: S-EPMC12835292 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature