Anti-NMDA receptor encephalitis unmasking Sjogren's disease: a case report and literature review.

ABSTRACT: Anti-N-methyl-D-aspartate (NMDA) receptor encephalitis is an autoimmune central nervous system (CNS) disorder mediated by antibodies against the GluN1 subunit of the NMDA receptor. Sjögren's disease (SjD) is a systemic autoimmune disorder that involves exocrine glands as a primary target. However, CNS manifestations, including the coexistence of other CNS diseases, may also occur. While antibodies against the NMDA receptor, targeting the GluN2 subunits, have been associated with SjD and neurological symptoms, the presence of GluN1 antibodies is rarely described, and the co-occurrence of these two disorders has been scarcely reported. Here, we present a case in which anti-NMDA receptor encephalitis and SjD were identified concurrently during the initial workup. The patient experienced three

SUBMITTER: Dimitrov G 

PROVIDER: S-EPMC12835306 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature