Sex differences in APOE- and PICALM-related cognitive profiles in healthy middle-aged adults.

ABSTRACT:

Introduction

The APOE ε4 and PICALM GG genotypes are strong genetic risk factors for Alzheimer's disease. This study aimed to identify cognitive subgroups using unsupervised machine learning and to investigate the influence of APOE and PICALM genotypes on cognitive performance.

Material and methods

Cognitive, genetic and demographic data from 192 healthy middle-aged adults (50-63 years) from the PEARL-Neuro Database were analyzed using agglomerative hierarchical clustering. Neuropsychological tests included the California Verbal Learning Test, Raven's Progressive Matrices, and the Edinburgh Handedness Inventory. Subsequent analyses used linear regression models to assess the effects of APOE, PICALM, and their interaction on cognitive

SUBMITTER: Bednorz A 

PROVIDER: S-EPMC12835333 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature