Neutrophil-to-lymphocyte ratio for primary risk stratification in acute pancreatitis: a systematic review and meta-analysis.

ABSTRACT:

Background

Early risk stratification in acute pancreatitis should address not only the probability of severe disease but also the timely prediction of persistent organ failure, (POF) infectious complications [including infected pancreatic necrosis (IPN)], and mortality. The neutrophil-to-lymphocyte ratio (NLR) is a low-cost, first-line biomarker that is readily obtainable within the initial 24-48 h.

Objective

To evaluate the clinical utility of the NLR for predicting a severe disease course, persistent organ failure, infection, and mortality across predefined, time-specific measurement windows.

Methods

We conducted a systematic review with meta-analytic synthesis of studies assessing the NLR at admission and during the first two days of hospitalization. Random-effects

SUBMITTER: Chooklin S 

PROVIDER: S-EPMC12835348 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature