Association between night shift work and risk of osteoporosis and osteoporosis-related pathological fracture.

ABSTRACT:

Background

Night shift work may increase the risk of various diseases, this study aims to explore the associations of both past and current night shift rotations with osteoporosis and its related fracture risks, and to evaluate the role of potential mediators further in the UK biobank.

Methods

We investigated 276,774 UK Biobank participants with current paid employment or self-employed work, alongside 75,120 individuals with lifetime occupational history information. The multivariable-adjusted logistic regression and Cox proportional hazard models were utilized to analyze the potential links between night shift work and the incidence of OP. Moreover, stratified analyses and interaction tests were applied to explore potential modifications.

Results

A total of 276,774 p

SUBMITTER: Yang D 

PROVIDER: S-EPMC12835380 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature