Molecular resistance mechanisms to newly approved antibiotics (2017-2025) in WHO priority pathogens.

ABSTRACT: The relentless rise of antimicrobial resistance (AMR) poses a critical threat to global public health, rendering once-effective therapies obsolete. In response, several novel antibiotics have been developed in recent years. This review systematically summarizes the molecular resistance mechanisms that World Health Organization (WHO) priority bacterial pathogens have already deployed against the 15 new antibiotics approved between 2017 and 2025, including β-lactam/β-lactamase inhibitors (cefiderocol, ceftazidime-avibactam, meropenem-vaborbactam), tetracycline derivatives (eravacycline, omadacycline), a pleuromutilin (lefamulin), an aminoglycoside (plazomicin), and a fluoroquinolone (delafloxacin). We detail how pathogens utilize four primary strategies to overcome these last-line agents: en

SUBMITTER: Sartori M 

PROVIDER: S-EPMC12835396 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature