Hemolysis correction factor in the reporting of serum neuron-specific enolase - Clinical utility in neuroprognostication after cardiac arrest.

ABSTRACT:

Background

Neuron-specific enolase (NSE) from 48 h after cardiac arrest is the only biomarker of brain injury with recommended cut-offs for use in neuroprognostication. Hemolysis elevates levels of NSE and may result in false outcome predictions.

Methods

A correction-factor for hemolysis in reporting of levels of NSE was established and evaluated in (1) incoming routine samples and (2) biobank samples from 48 h after cardiac arrest from the SweCrit biobank. Comparisons were made with three methods for handling hemolysis: Hemolysis Index (HI) 30 mg/dL or HI 50 mg/dL as the highest acceptable level of hemolysis, or a graded approach.

Results

Five-hundred and fifty-six routine samples and 263 biobank samples were analyzed. A correction factor of 0.33 µg/L per HI signific

SUBMITTER: Jungar C 

PROVIDER: S-EPMC12835405 | biostudies-literature | 2026 Mar

REPOSITORIES: biostudies-literature