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Comprehensive pan-cancer analysis of TRAP1 and its experimental validation in hepatocellular carcinoma.


ABSTRACT:

SUBMITTER: Shan S 

PROVIDER: S-EPMC12835488 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature

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Comprehensive pan-cancer analysis of TRAP1 and its experimental validation in hepatocellular carcinoma.

Shan Shuaikun S   Wang Tiantian T   Sun Fangzheng F   Zhao Ludong L   Liang Shuang S   Wang Zhenghua Z  

Discover oncology 20251220 1


PURPOSE: Tumor necrosis factor receptor-associated protein 1 (TRAP1) is essential for carcinogenesis and the advancement of cancer, making it a promising therapeutic target in oncology. Nevertheless, comprehensive bioinformatic analyses of TRAP1 across diverse cancer types are limited. Herein, we analyzed TRAP1 across all cancer types, focusing on its expression in relation to prognosis, immune infiltration, and the mammalian target of rapamycin and receptor tyrosine kinase signaling pathways. M  ...[more]

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