Drug-induced intestinal obstruction: insights from the FDA Adverse Event Reporting System.

ABSTRACT:

Background

Intestinal obstruction is a severe abdominal condition that can be triggered by various medications; however, the drugs most strongly and frequently linked to this adverse event (AE) remain insufficiently defined in the current medical literature.

Objectives

This study sought to systematically identify and evaluate medications most strongly and consistently associated with intestinal obstruction by analyzing real-world evidence from a large pharmacovigilance database.

Design

We conducted a retrospective, observational pharmacovigilance study.

Methods

Reports submitted to the U.S. FDA Adverse Event Reporting System (FAERS) between January 2004 and June 2024 were analyzed. Disproportionality analyses using the Reporting Odds Ratio (ROR), Proportional R

SUBMITTER: Li H 

PROVIDER: S-EPMC12835516 | biostudies-literature | 2026

REPOSITORIES: biostudies-literature