Applicability of colon capsule endoscopy in FIT-positive individuals unable or unwilling to undergo colonoscopy within a colorectal cancer screening programme: a prospective multicentre study.

ABSTRACT:

Background

Colorectal cancer (CRC) screening programmes commonly use the Faecal immunochemical test (FIT) followed by colonoscopy. When colonoscopy is not feasible, computed tomography colonography (CTC) serves as an alternative. However, CTC has limitations, such as lower sensitivity for smaller polyps and radiation exposure. Colon capsule endoscopy (CCE) is a non-invasive alternative that may improve polyp detection in FIT-positive individuals.

Objectives

To evaluate the feasibility of CCE in FIT-positive participants from the Dutch CRC screening programme who are unable or unwilling to undergo colonoscopy.

Design

Prospective multicentre, interventional study.

Methods

FIT-positive participants ingested the PillCam^® Colon 2 capsule. Colonoscopy was

SUBMITTER: Marijnissen FE 

PROVIDER: S-EPMC12835520 | biostudies-literature | 2026 Jan-Dec

REPOSITORIES: biostudies-literature