Identifying Susceptibility Genes and Shared Genetic Architecture for Longevity and Muscle Weakness.

ABSTRACT:

Background

Longevity and muscle strength are heritable traits, and age-related muscle weakness is a major contributor to disability in older adults. However, the susceptibility genes and shared genetic mechanisms underlying lifespan and sarcopenia remain unclear. This study aimed to identify genes associated with longevity and muscle weakness and to characterize their shared genetic architecture.

Methods

We integrated the largest genome-wide association studies (GWAS) on longevity (age > 90th: n = 11 262 cases; age > 99th: n = 3484 cases) and muscle weakness (European Working Group on Sarcopenia in Older People (EWGSOP): n = 48 596 cases; Foundation for the National Institutes of Health (FNIH): n = 20 335 cases) with Genotype-Tissue Expression (GTEx) v8 multi-tissue expressi

SUBMITTER: Lin Y 

PROVIDER: S-EPMC12835543 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature