Associations of phenotypic age acceleration, genetic risk, and lifestyle with chronic digestive diseases: A large-scale longitudinal cohort study.

ABSTRACT:

Background

Phenotypic age acceleration (PhenoAgeAccel) is a promising biological aging metric, but its associations with chronic digestive disease risk are unclear. This study evaluated these associations and assessed modification by genetic risk and lifestyle.

Methods

We analyzed 292,639 UK Biobank participants. PhenoAge and PhenoAgeAccel were calculated using a validated algorithm based on clinical biomarkers. Cox proportional hazards models estimated associations of PhenoAgeAccel, genetic risk, and lifestyle with incident chronic digestive diseases, including interaction and stratified analyses. Variance decomposition quantified contributions of aging, genetics, and lifestyle.

Results

Over a median 13.67-year follow-up, PhenoAgeAccel > 0 (accelerated aging) was ind

SUBMITTER: Xiang S 

PROVIDER: S-EPMC12835587 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature