Efficacy and Safety of Different Neoadjuvant Treatment Regimens in Locally Advanced Squamous Head and Neck Cancer.

ABSTRACT:

Background

Head and neck squamous cell carcinoma (HNSCC), which constitutes approximately 90% of all head and neck cancers, represents a significant global health burden. A concerning trend is the rising incidence, particularly among younger populations, which has been partly attributed to human papillomavirus (HPV) infection. While treatment outcomes are favorable for early-stage disease, approximately 60% of patients are diagnosed with locally advanced HNSCC (LA-HNSCC), for whom prognosis remains suboptimal. Induction chemotherapy, such as the TPF regimen, is often used to reduce tumor burden but is limited by substantial toxicity. Currently, no global consensus exists on the optimal neoadjuvant approach for LA-HNSCC. This network meta-analysis aims to comprehensively compare the

SUBMITTER: Ding YT 

PROVIDER: S-EPMC12835624 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature