Distinct subcortical neuroanatomic profiles of treatment-resistant schizophrenia: structural magnetic resonance imaging study.

ABSTRACT:

Background

Understanding the neuroanatomical correlates of treatment response in schizophrenia is crucial for improving clinical stratification and clarifying underlying pathophysiological mechanisms.

Aims

To examine subcortical volumetric differences across clinically defined schizophrenia treatment-response subgroups.

Method

T1-weighted structural magnetic resonance imaging data were analysed from 109 participants, including 79 individuals with schizophrenia and 30 healthy controls. Patients were categorised into three distinct treatment response groups: ultra-treatment-resistant (UTR; n = 22), clozapine-responsive (n = 28) and first-line antipsychotic responsive (FLR; n = 29). Group differences were examined across 33 regions of interest, inclu

SUBMITTER: Sungur I 

PROVIDER: S-EPMC12835719 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature