Impact of Anesthesia With Propofol on Epileptic Discharges Recorded by Stereo-Electroencephalography in Pediatric Epilepsy Surgery.

ABSTRACT:

Objective

This study aimed to evaluate the influence of anesthesia with propofol on epileptic discharges recorded by stereo-electroencephalography (SEEG) during pediatric epilepsy surgery.

Methods

We enrolled 30 pediatric patients (aged 2-14 years) undergoing epilepsy surgery between June 2022 and November 2023. SEEG recordings were obtained under different states of consciousness: awake, sleep, and anesthesia. We analyzed the power spectral density (PSD) across frequency bands and quantified the number of interictal spikes and high-frequency oscillations (HFO) including ripples and fast ripples (FRs).

Results

There was a significant reduction in the number of spikes, particularly within the seizure onset zone (SOZ), while ripples and FRs increased under general anest

SUBMITTER: Liu C 

PROVIDER: S-EPMC12835890 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature