1-Year Clinical Outcome Post-Myasthenic Crisis: A Multicenter Prospective Study in China.

ABSTRACT:

Background

Myasthenic crisis (MC) affects 10%-20% of myasthenia gravis patients and is life-threatening with significant economic burden, yet its long-term outcomes remain poorly understood. This prospective multicentre study aimed to evaluate 1-year clinical outcomes after MC.

Methods

This study enrolled patients with MC between December 2018 and October 2024 and prospectively followed at 1, 2, 3, 6, and 12 months post-MC. Outcome measures included Myasthenia Gravis Foundation of America (MGFA) postintervention status (PIS) classification at 1 year after MC, all-cause mortality, and complications.

Results

The cohort comprised 277 patients with 282 MC episodes with a follow-up duration of 29.16 ± 15.93 months. The in-hospital mortality was 5.05% (14/277), while the al

SUBMITTER: Huan X 

PROVIDER: S-EPMC12836041 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature