Molecular and Transcriptional Signatures of Gray Matter Volume Alterations Associated With Depressive Symptoms in Mild Cognitive Impairment.

ABSTRACT: Depressive symptoms are common in individuals with mild cognitive impairment (MCI) and may contribute to an increased risk of dementia. However, the neuroanatomical correlates and underlying pathophysiological mechanisms of depressive symptoms in MCI remain largely unknown. We aimed to elucidate alterations in gray matter volume and the related molecular and genetic bases in MCI patients with depressive symptoms. A total of 177 participants were enrolled, comprising 57 MCI patients with depressive symptoms (D-MCI), 60 MCI patients without depressive symptoms (nD-MCI), and 60 healthy controls (HCs). Gray matter morphological differences among groups were examined using voxel-based morphometry. The associations between depressive symptom-related morphological alterations and functional chara

SUBMITTER: Xu H 

PROVIDER: S-EPMC12836043 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature