Unveiling the prognostic role of FABP4 in early-onset colorectal cancer through big data analysis and preliminary clinical validation.

ABSTRACT:

Background

Early-onset colorectal cancer (EOCRC), characterized by greater aggressiveness and advanced stage at diagnosis, is increasing globally. This study aimed to identify suitable prognostic biomarkers for EOCRC.

Methods

Gene expression and clinical data from TCGA and GEO (GSE39582, GSE17536, and GSE17537) datasets were analyzed. Differential expression, univariate and multivariate Cox regression, and correlation analyses were performed. Immune status was evaluated using ESTIMATE and CONSENSUS TME algorithm. Immunotherapy and chemotherapy response was predicted via the TIDE and oncoPredict algorithm, respectively. Candidate signatures were validated in clinical samples from three EOCRC patients using qRT-PCR.

Results

Fatty Acid Binding Protein 4 (FABP4) was ident

SUBMITTER: Wu Y 

PROVIDER: S-EPMC12836056 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature