Serum proteome analysis detects early molecular signatures of disease progression in IgA nephropathy.

ABSTRACT:

Background

Immunoglobulin A nephropathy (IgAN) is a common cause of chronic kidney disease (CKD) and identifying early molecular signatures is crucial for IgAN risk stratification and timely intervention. In this study we used serum proteomics to investigate molecular differences between IgAN patients who progressed and those who remained stable before separation in kidney function became apparent.

Methods

Serum samples from 40 adults with biopsy-proven IgAN were analysed and classified as progressors (PRs; n = 13) or non-progressors (NPs; n = 27) based on the estimated glomerular filtration rate slope over a 5- to 6-year follow-up. Samples underwent protein depletion, SP3 digestion, tandem mass tag labelling and liquid chromatography-tandem mass spectrometry a

SUBMITTER: Chen TJ 

PROVIDER: S-EPMC12836095 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature