Low protein diet with personalized support in advanced chronic kidney disease: association with disease progression, dialysis delay and mortality.

ABSTRACT:

Background

Despite therapeutic strategies to manage comorbidities and risk factors associated with chronic kidney disease (CKD), a significant number of patients continue to progress toward kidney failure. The role of low protein diets (LPDs) in delaying the need for kidney replacement therapy (KRT) remains a subject of ongoing discussion. Real-world studies offer insights into the risks, implementation and feasibility of LPDs.

Methods

We retrospectively evaluated the efficacy of a moderate LPD (0.6-0.7 g/kg/day) proposed to all newly referred patients with advanced CKD. Survival and need for dialysis were compared between patients who choose an LPD and those who did not. Follow-up was otherwise identical in both groups.

Results

Between January 2021 and December 2023,

SUBMITTER: Vischini G 

PROVIDER: S-EPMC12836100 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature