Eosinophilic granulomatosis with polyangiitis related giant coronary aneurysm leading to acute myocardial infarction: a case report.

ABSTRACT:

Background

Eosinophilic granulomatosis with polyangiitis (EGPA) is a rare, multisystem autoimmune disorder characterized by adult-onset asthma, peripheral eosinophilia, and small- to medium-vessel vasculitis. Cardiac involvement is a leading cause of mortality in EGPA. A case exhibiting progressive enlargement of coronary aneurysms despite normal peripheral eosinophil counts and treatment consistent with guideline-recommended immunosuppressive therapy is exceedingly rare.

Case summary

A 55-year-old woman with a 7-year history of EGPA presented to our institution with acute chest pain. Four years prior to the current presentation, the patient underwent coronary angiography for acute coronary syndrome at another hospital, which revealed coronary ectasia. Consequently, low-dose

SUBMITTER: Okamoto K 

PROVIDER: S-EPMC12836111 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature