A feasibility study of functional preservation in craniospinal irradiation with photon for pediatric medulloblastoma.

ABSTRACT:

Background

Craniospinal irradiation (CSI) is essential for treating pediatric medulloblastoma (MB) but causes significant long-term toxicities. Existing dose-reduction or partial-sparing strategies improve neurocognitive outcomes but may compromise survival or fail to address other late effects.

Methods

A new functional preservation CSI (FP-CSI) technique was developed to spare the hippocampus, hypothalamic-pituitary axis (HPA), cochlea, and scalp while ensuring homogeneous vertebral coverage. Eight pediatric patients with average-risk MB were retrospectively planned with volumetric modulated arc therapy (VMAT) using both FP-CSI and standard CSI (S-CSI). Dosimetric parameters for the planning target volume (PTV) and organs at risk (OARs), radiobiological effects, plan robust

SUBMITTER: Wang K 

PROVIDER: S-EPMC12836293 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature