Urokinase Plasminogen Activator Deficiency Delays the Development of Obesity and Metabolic Sequelae.

ABSTRACT:

Background

Obesity predisposes individuals to multiple pathologies, including metabolic dysfunction-associated steatotic liver disease and diabetes. Although it is known that accumulation of proinflammatory macrophages within adipose tissues drives adiposity and provokes obesity-linked sequelae, the molecular mechanisms that provoke macrophage dysfunction in obesity remain elusive. Macrophages express high levels of uPA (urokinase plasminogen activator), and uPA has been implicated in leukocyte migration.

Methods

Human adipose tissues from patients receiving bariatric surgery were collected and analyzed for uPA protein levels. To determine the impact of uPA in adipose tissue and subsequent high-fat diet (HFD)-induced weight gain and metabolic diseases, a novel mouse model wi

SUBMITTER: Hur WS 

PROVIDER: S-EPMC12836328 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature