Resin Glycosides from <i>Ipomoea funis</i> as Inhibitors of P-Glycoprotein in Multidrug-Resistant Breast Carcinoma Cells.

ABSTRACT: Ipomoea funis Cham. & Schltdl. is an endemic vine found in central Mexico. The use of heart-cutting and peak-shaving methods in recycling preparative HPLC yielded funisin I (1), an undescribed resin glycoside, along with the known intrapilosins I (2) and V (3). Funisin I features operculinic acid A (6) as the oligosaccharide core. The structural similarities observed for funisin I align with those previously reported for purginoside I (4); however, a difference was apparent in the occurrence of dodecanoic and (-)-(2R)-methylbutyric acids as the long- and short-chain fatty acid substituents in compound 1. Moreover, the structure of the previously described acutacoside F (5) was corrected by comparing its NMR data with those of <

SUBMITTER: Flores-Tafoya PJ 

PROVIDER: S-EPMC12836347 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature