Salinirifamycins A-E: Rifamycin S Derivatives from the Brazilian Marine Actinomycete <i>Salinispora arenicola</i>.

ABSTRACT: Five new rifamycin derivatives, named salinirifamycins A-E (1-5), were isolated from a Brazilian marine Salinispora arenicola (BRA-213) strain extract. The structures of the new rifamycins were elucidated using a combination of NMR, IR, UV, and MS spectroscopic techniques, quantum-chemical calculations (DFT-calculated ¹³C NMR chemical shifts and DP4+ probability analysis), and comparison of experimental and calculated electronic circular dichroism (ECD) spectra. Compounds 1, 2, and 4 displayed antibacterial activity against Staphylococcus aureus and Enterococcus faecalis with MIC values ranging from 2.0 to 125.0 μg/mL, whereas 5 exhibited an MIC of 0.02 μg/mL to S. aureus, similar to the positive control rifam

SUBMITTER: Batista da Silva A 

PROVIDER: S-EPMC12836363 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature