Prevalence and prognostic value of baseline and post-treatment renal insufficiency in colorectal cancer patients: a large retrospective cohort study of 10,581 patients in Shanghai, China (2019-2023).

ABSTRACT:

Background

Baseline renal insufficiency (RI) and post-treatment renal insufficiency (PTRI) are prevalent comorbidities in patients with colorectal cancer (CRC). However, the prevalence, risk factors, and prognostic significance of these conditions remain controversial.

Methods

This is a retrospective cohort study, which included all CRC patients treated at Shanghai Changhai Hospital (2019-2023). Multivariate logistic and Cox survival analyses were used to explore risk factors and prognostic value of baseline RI and PTRI.

Results

Among 10,581 CRC patients, the prevalence rates of RI-related parameters were: baseline RI (32.4%), hematuria (31.2%), elevated serum cystatin C (CysC) (17.4%), proteinuria (12.3%), elevated serum uric acid (8.7%), elevated serum creatinine (4

SUBMITTER: Li J 

PROVIDER: S-EPMC12836388 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature