Influence of omega-3 fatty acids on post-traumatic stress disorder: prospective cohort study and Mendelian randomisation findings.

ABSTRACT: Background and Objectives: Omega-3 fatty acids have positive effects on mental health. This study aimed to explore the association between plasma omega-3 fatty acid levels and the risk of post-traumatic stress disorder (PTSD).Methods: This study explored the association between plasma omega-3 fatty acid levels and risk of developing PTSD. In total, 82,391 adults from the UK Biobank were included in this study. PTSD screening was performed using a PCL-6 score greater than 13, based on responses to the online mental health questionnaire. Multivariate logistic regression analyses were performed to evaluate the association between omega-3 fatty acid levels and the risk of PTSD. Additionally, a two-sample bidirectional Mendelian randomisation (MR) analysis was used to investigate

SUBMITTER: Chen M 

PROVIDER: S-EPMC12836410 | biostudies-literature | 2026 Dec

REPOSITORIES: biostudies-literature