Bilateral carcinoid heart disease without intracardiac shunt in a patient with advanced functional small bowel neuroendocrine tumour: a clinical conundrum.

ABSTRACT:

Background

Carcinoid heart disease (CHD) is a known complication of advanced functional neuroendocrine tumours (NETs), almost exclusively affecting right-sided cardiac valves. Left-sided involvement is rare and usually attributed to intracardiac shunting or pulmonary sources of serotonin. This case report highlights a rare presentation of CHD involving left- and right-sided valves in the absence of an anatomic shunt or bronchopulmonary NET.

Case summary

A 67-year-old woman with a long-standing, functional, small bowel Grade 1 NET and metastatic liver and peritoneal disease presented with worsening dyspnoea and peripheral oedema. She had a 10-year disease history, previously managed with debulking surgery, somatostatin analogues, peptide receptor radionuclide therapy (PRRT),

SUBMITTER: Byer SH 

PROVIDER: S-EPMC12836417 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature