Vibration-Mediated Recovery of Irradiated Osteocytes and Their Regulatory Role in Breast Cancer Bone Metastasis.

ABSTRACT: Radiotherapy is a cornerstone of breast cancer treatment, but it can unintentionally damage bone, causing bone loss and pain, with no currently effective therapeutic strategy available. While chemically mediated radioprotection is extensively studied, mechanically mediated radioprotection remains underexplored. Given its safety and efficacy, this work examines the potential of low-magnitude, high-frequency (LMHF) vibration as a non-invasive intervention to protect irradiated bone, focusing on osteocytes-the primary mechanosensors and regulators whose functions extend to modulating breast cancer bone metastasis. These results demonstrate that LMHF vibration (0.3 g, 60 Hz, 1 h) mitigates osteocyte apoptosis and upregulates cytoskeletal markers following 8 Gy irradiation. LMHF vibration appli

SUBMITTER: Song X 

PROVIDER: S-EPMC12836450 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature