Formulating Smart All-in-One Chitosan Hydrogel for High Performance Wound Dressing.

ABSTRACT: The poor mechanical and film formation properties of chitosan hydrogel limit its application as a wound dressing. To solve this shortcoming, chitosan-graft-poly(N-isopropyl acrylamide) (PNIPAAm) and crosslinked with polyvinyl alcohol/polyvinyl pyrollidone (PVA/PVP) blend polymer is designed to form the thermosensitive hydrogel. After that, silver nanoparticles (AgNPs), synthesized by the co-reduction method, are added into the chitosan hydrogel network to provide better antibacterial ability. When the temperature is above 32 °C, the hydrogel showed a decrease in particle size and transmittance, which proved that it is a thermal responsive material. Chitosan hydrogels are evaluated for their thermal properties, mechanical properties, swelling effects, antibacterial properties, and wound hea

SUBMITTER: Lin CC 

PROVIDER: S-EPMC12836463 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature