Effect of omp10 or omp19 deletion on Brucella abortus outer membrane properties and virulence in mice.

ABSTRACT: The distinctive properties of Brucella outer membrane have been considered to be critical for Brucella sp. virulence. Among the outer membrane molecules possibly related to these properties, Omp10 and Omp19 are immunoreactive outer membrane lipoproteins. Moreover, these proteins of Brucella could constitute a new family of outer membrane proteins specifically encountered in the family RHIZOBIACEAE: We evaluated the impact of omp10 or omp19 deletion on Brucella abortus outer membrane properties and virulence in mice. The omp10 mutant was dramatically attenuated for survival in mice and was defective for growth in minimal medium but was not impaired in intracellular growth in vitro, nor does it display clear modification of the outer membrane properties. Significantly fewer brucellae were re

SUBMITTER: Tibor A 

PROVIDER: S-EPMC128365 | biostudies-literature | 2002 Oct

REPOSITORIES: biostudies-literature