Esophageal microbiome correlates with post-esophagectomy anastomotic leak in cancer patients.

ABSTRACT:

Background

Despite continuous improvement in long-term survival after esophagectomy, potential serious post-operative complications, such as anastomotic leaks (ALs), still occur. Several risk factors for ALs have been proposed, including environmental factors. Our main objective was to examine the correlation of esophageal tumor microbiome composition and functional profile with ALs. Additionally, we analyzed the microbiome of esophageal tumors and their potential correlation with clinical features of the patients.

Materials and methods

Surgical specimens of esophageal tumors and adjacent normal tissues were collected from consecutive patients who underwent an esophagectomy. Formalin-fixed paraffin-embedded (FFPE) tissue samples were processed using 16S ribosomal DNA multipl

SUBMITTER: Naddaf R 

PROVIDER: S-EPMC12836591 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature