The complexity of finding fit-for-purpose real-world data for oncology patients with rare <i>NTRK</i> gene fusions and a novel solution.

ABSTRACT:

Background

Multiple data sources suggest low frequencies of neurotrophic tyrosine receptor kinase (NTRK) gene fusions across common solid tumors, ranging from 0.18% to 0.30%, making it a relevant target for a tumor-agnostic development using a single-arm basket trial. The objective of this study was to explore a multifaceted approach to building a pooled real-world dataset of patients with select solid tumors harboring NTRK1-3 gene fusions from multiple clinicogenomic databases (CGDBs) and clinical site sources.

Materials and methods

A novel approach was explored for identifying patients with NTRK gene fusion-positive solid tumors from real-world data (RWD) sources through existing CGDBs and global clinical site surveys. CGDBs were assessed for inclusion

SUBMITTER: Pan X 

PROVIDER: S-EPMC12836673 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature