Loss of Y chromosome and its implications in male amyotrophic lateral sclerosis: insights from the UK Biobank.

ABSTRACT:

Background

Amyotrophic lateral sclerosis (ALS) shows a male predominance, yet the underlying mechanism remains unclear. Although the loss of Y chromosome (LOY) in peripheral blood - a male-specific genetic alteration - has been implicated in certain neurodegenerative disorders (NDDs), its association with ALS in men remains unexplored and has not been explored.

Methods

We focused on men in the UK Biobank to investigate whether LOY influences the risk and prognosis of ALS. Initially, the LOY level for each male participant was determined using sequencing data. Subsequently, Cox proportional hazards (Cox PH) model analysis was used to assess LOY-associated risk of ALS; thirdly, piecewise linear regression, Kaplan-Meier, and Cox PH analysis assessed LOY's associations with ALS

SUBMITTER: Su WM 

PROVIDER: S-EPMC12836765 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature