European screening platform for EORTC clinical trials in advanced colorectal cancer 'SPECTAcolor'.

ABSTRACT:

Background

The European Organisation for Research and Treatment of Cancer (EORTC) has established the Screening Platform for Efficient Clinical Trial Access for COLORectal Patients (SPECTAcolor), which provides centralized molecular testing to screen patients for and facilitate enrollment in molecular-based therapeutic trials.

Materials and methods

Patients with advanced or metastatic colorectal malignancies were recruited in 11 European countries. Patients' paraffin-embedded material was tested for KRAS , NRAS, BRAF, and PI3K microsatellite instability-high (MSI-H) (not routine at the time of recruitment) and later by a 300-gene next-generation sequencing panel. RNA profiling was carried out in a subset of patients. Results were reported to the centers

SUBMITTER: Folprecht G 

PROVIDER: S-EPMC12836792 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature