Interaction effects of environmental factors with white blood cell profiles on mycobacterial pulmonary diseases: a case-control study.

ABSTRACT:

Background

Mycobacterial pulmonary diseases remain a significant global health concern. This study investigates the interaction effects of relative humidity (RH), temperature, and fine particular matter (PM_2.5) with immune profiles, reflected by white blood cell (WBC) counts, on pulmonary drug-susceptible tuberculosis (DS-TB), multidrug-resistant TB (MDR-TB), and non-tuberculous mycobacteria (NTM) disease.

Methods

This case-control study of 1,398 participants, including 409 cases (203 DS-TB, 151 MDR-TB, and 55 NTM) and 989 controls, assessed individual exposure to RH, temperature, and PM_2.5, in mean and difference over 1-month interval, using radial basis function interpolation. Logistic regression models evaluated the associations between environmental

SUBMITTER: Tran XN 

PROVIDER: S-EPMC12836817 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature