[¹⁸F]F-FAPI PET/CT and LAparoscopy in STagIng advanced gastric Cancer: a multicenter prospective study (PLASTIC-3 study).

ABSTRACT:

Background

Treatment decisions for locally advanced gastric adenocarcinoma rely on staging with gastroscopy, computed tomography (CT), and staging laparoscopy (SL). However, CT often fails to detect peritoneal and other distant metastases, and SL is an invasive procedure with complication risks and costs. Therefore, an accurate non-invasive imaging biomarker to detect such metastases could improve the care for gastric cancer patients. Radiolabeled fibroblast-activating protein inhibitors (FAPI), targeting stromal cancer-associated fibroblasts, are promising radiotracers. Preliminary Asian studies indicate that FAPI PET/CT outperforms [¹⁸F]FDG PET/CT in tracer uptake, tumor-to-background ratio and diagnostic sensitivity in gastric cancer. However, larger studies using FAP

SUBMITTER: Triemstra L 

PROVIDER: S-EPMC12836824 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature