Zinc pyrithione impairs iron-sulfur cluster biogenesis in Mycobacterium tuberculosis.

ABSTRACT:

Background

Tuberculosis remains a major global health threat, especially with the increasing prevalence of drug-resistant Mycobacterium tuberculosis (Mtb). There is an urgent need to develop new antibiotics with novel mechanisms of action. Zinc pyrithione (ZnPT), a bidentate metal-chelating agent, displays potent in vitro activity against bacteria and fungi. This study aimed to evaluate the antimycobacterial activity of ZnPT and to explore its potential mechanisms.

Methods

The bactericidal activity of ZnPT against Mtb strains was evaluated using minimum inhibitory concentration and minimum bactericidal concentration assays. The role of copper was assessed through metal chelator supplementation studies, while intracellular metal accumulation was quantified using inductively c

SUBMITTER: Wang L 

PROVIDER: S-EPMC12836896 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature