Cumulative of c-reactive protein-triglyceride glucose index exposure and risk of diabetes in middle-aged and older Chinese adults: findings from a national longitudinal cohort.

ABSTRACT:

Background

The C-reactive protein-triglyceride glucose index (CTI) was a new biomarker to assess systemic inflammation and metabolic disturbances. However, research on its association with diabetes remained limited. This study aimed to investigate the association between CTI and the risk of developing new-onset diabetes.

Methods

This study employed a prospective observational design, focusing on middle-aged and elderly Chinese adults. Multivariate Cox regression analysis were used to assess the dose-response association between the CTI and the cumulative exposure of CTI (CumCTI) with diabetes risk. The K-means clustering was employed to classify the CTI trajectories.

Results

A total of 3,742 participants without diabetes were enrolled in this study. Over a 5-year foll

SUBMITTER: Zhou YF 

PROVIDER: S-EPMC12836901 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature