Macrophages and iNOS contribute to the effects of dural prolactin and repeated stress in mouse migraine models.

ABSTRACT:

Background

Migraine impacts 15% of the global population, predominantly women. Previous studies have shown a role for prolactin in animal migraine models induced by either stimulation of the dura mater or repeated stress exposure. However, the site of prolactin action is not fully known nor are its downstream mechanisms. This study investigated the potential downstream mechanisms and the cell types involved in prolactin- and repeated stress-induced migraine-like responses.

Methods

Two preclinical migraine models were used in this study, dural stimulation and repeated restraint stress. Dural injections in mice enabled drug delivery to the dura mater through the intersection of the lambdoidal and sagittal sutures. Additionally, a model of repeated stress-induced periorbital hy

SUBMITTER: Mei HR 

PROVIDER: S-EPMC12836902 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature