Wnt10a exhibit spatiotemporal singularity in the temporal changes of angiogenesis in regenerated pulp-like tissue.

ABSTRACT:

Background

In tooth development, the Wnt/β-catenin pathway has been shown to play a crucial role in tooth germ formation and tooth differentiation. Regeneration can be considered a replay of development. Understanding and reproducing the involvement of Wnt10a-which is reported to be the causative gene for congenital multiple tooth absence and participates in tooth development with spatiotemporal specificity-in pulp regeneration is essential for realizing dental regenerative medicine. Therefore, this study was initiated based on the concept that evaluating the dynamics of Wnt10a during angiogenesis, which is thought to occur early in dental pulp regeneration, could contribute to a more detailed elucidation of the dental pulp regeneration mechanism.

Methods

Deciduous dental pu

SUBMITTER: Iida N 

PROVIDER: S-EPMC12836903 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature