Mediating role of aging and obesity in the relationship between dietary index for gut microbiota and metabolic syndrome and its potential regulatory mechanisms.

ABSTRACT:

Background

The relationship between gut microbiota and metabolic syndrome (MetS) has attracted significant attention, with MetS comprising components like abdominal obesity, dysglycemia, dyslipidemia, and hypertension. The dietary index for gut microbiota (DI-GM) has also been developed as a standardized tool for assessing a balanced diet for the gut microbiota. Additionally, the interplay between aging and metabolism is important for understanding disease development. Nevertheless, the intrinsic regulatory mechanisms of factors such as aging in the association between the DI-GM and MetS have not been thoroughly investigated.

Methods

Participants were recruited from multiple cycles of National Health and Nutrition Examination Surveys (NHANES). In this study, weighted logisti

SUBMITTER: Yang H 

PROVIDER: S-EPMC12836930 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature